Chemistry 2223B Lecture Notes - Glycogen Phosphorylase, Glycogen Synthase, Blood Sugar

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Carbohydrate storage as glycogen: glucose is a good energy source we oxidize it to get atp, excess glucose is saved for later makes glycogen out of it. Uses utp not atp", it has the same sort of structure. Allosteric regulation in liver: same thing is going on in liver, the enzymes are slightly different have different isoforms located in different tissues so different indicators. Instead of atp concentration regulating it, glucose regulates it. Lots of glucose around the liver will deactivate glycogen phosphorylase (don"t need more glucose) Control by phosphorylation in liver & muscle: these enzymes are also regulated by phosphorylation, phosphorylate glycogen synthase and it is inactivated, phosphorylate glycogen phosphorylase and it is activated, when phosphorylated the allosteric regulation tends to not matter. Insulin is released when blood glucose is high leads to dephosphorylation: glycogen synthase is active makes sense because we have lots of glucose.

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