KINE 1020 Lecture Notes - Endoplasmic Reticulum, Lower Motor Neuron, Alpha Motor Neuron
22 Apr 2014
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Msk disorders- who classifications: muscle structure/ function, transient and reversal decrease in muscle function. Muscle fatigue mins/hrs: functional/physical activity limitation, restrictions. Injury or damage and associated pain leading to impaired movement- days to years. Injury leading to chronic disability, degeneration and loss of muscle (muscles diseases) ongoing. Aging: functional limitations and muscle loss due to sarcopenia. Fatigue: skeletal muscle fatigue: a condition in which there is a loss in the capacity for developing force and/or velocity of muscle resulting from muscle activity under a demand/load which is reversible by rest. Hypothesis: ca hypothesis, metabolic hypothesis, breakdown and degradative hypothesis. Impact on neuromuscular junction (nmj: nmj (minimal electrophysiological evidence, no biochemical evidence that nmj blockage is a problem. Ryr protein loses function and become less effective. Not as much ca is coming out of sr at every action potential. Strength of action potential has also been decreased ontop of the protein being less effective.
