BMS 460 Lecture Notes - Colposcopy, Endocrinology, Ovarian Cyst
26 Apr 2014
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Exposure to chemicals that target preantral to ovulatory follicles may impair steroid production and thereby block ovulation, leading to infertility that may be reverted upon removal of exposure. Pahs, pesticides, plasticizers, metals, solvents and a variety of endocrine-disrupting chemicals impaired steroidogenesis, impaired ovulation, abnormal cyclicity infertility until the exposure is ceased. Androstenedione testosterone via 17 hsd e2 via cyp45019. Absence of menses in a phenotypic female by 16 years of age. Absence of menses for 3 or more years in a previously menstruating woman. Debilitating increase in the amount and duration of menstruation. Promote uterine contractions and ischemia of endometrial capillaries resulting in cramping pain. Treat by targeting the pathways for the synthesis of eicosanoids. Aspirin and other non-steroidal anti-inflammatory drugs (nsaids) inhibit cyclooxygenase. Associated with disorders such as leiomyomas, pelvic adhesions, or endometriosis. Prostaglandins produced by the endometrium in response to decrease in plasma p and. E (consequent to cl regression) cause vasoconstriction and uterine contractions.
