BMS 460 Lecture Notes - Collagen, Fibroblast, Ossification Center
26 Apr 2014
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Document Summary
Combination of type 2 diabetes, atherosclerosis, and high blood pressure. Obesity is not only an independent predictor of end-stage renal disease but is also correlated to albuminuria. Metabolic syndrome may affect as high as 25% of the us population. Obesity/diet, inactivity, genetic factors, lack of exercise, high calorie intake altered malonyl-coa/ampk. Altered malonyl-coa/ampk hypertension, myopathies, diabetes, insulin resistance, dyslipidemia, atherosclerosis, cvd, nafld/nash. Any degree of glucose intolerance that develops during pregnancy due to inability to secrete adequate insulin to overcome insulin resistance created by placental hormones. Pregnancy is a counter regulatory state with elevation of multiple blood glucose- elevating hormones. Gdm occurs because of insulin resistance as well as inability of the pancreas to make the additional insulin that is needed to support the placenta. Precipitated by the increasing levels of hormones such as chorionic somatomammotropin (placental lactogen), progesterone, cortisol, and prolactin all of which have counter-regulatory anti-insulin effects.
