BMS 460 Lecture Notes - Polyuria, Jigsaw Puzzle, Peptic Ulcer
26 Apr 2014
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Document Summary
Reduction in the width of the hypertrophic zone results in a 30% decrease in the longitudinal growth of bone. Laron syndrome, or laron-type dwarfism, is an autosomal recessive disorder characterized by an insensitivity to gh. It is caused by a variant of the gh receptor mainly associated with mutations in the gene for the gh receptor. These can result in defective hormone binding to the ectodomain or reduced efficiency of dimerization of the receptor after hormone occupancy. There are exceptionally low levels of igf-1 and its principal carrier protein, igf-binding protein 3. It causes short stature and a resistance to diabetes and cancer. Pituitary adenoma: functional somatotroph adenomas cause excess secretion of gh. Long bones do not grow in length but cartilage and membranous bones continue to grow. Impotence and loss of libido (amenorrhea in women) 99% of total body ca2+ (~1 kg) is in bones.
