CHEM 1004 Chapter Notes - Chapter 17: Ketone, Digitalis, Estrogen Receptor
1 May 2014
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Document Summary
Increase muscle mass: hormones and anabolic proteins: increase muscle mass and oxygen intake, anti-estrogenic drugs: tamoxifen: increase levels of male hormones, gluco-corticosteroids: increase stress endurance. Masking agents - react with the chemical species to be analyzed to change its properties and thus make it harder to detect. As with diuretics, they dilute the urine and produce lower levels of the banned substance, making it harder to detect. Anabolic steroids - all structurally related to testosterone . Detection: mass spectrometry of drug metabolites in urine. Testosterone - an anabolic (muscle enhancing) steroid. Epi-testosterone - is a stereoisomer, differing only in the chiral centre in the d-ring, but it has no anabolic effects. If t is administered, the excretion rate of urinary t increases and that of e decreases. When measuring the t/e ratio in urine the average for a man is 1 and rarely exceeds 4. Some tried adding additional epitestosterone to balance out the ratio.
