BIOL 1412 Lecture Notes - Hemostasis, Thrombin, Fibrinolysis

• School: University of Manitoba
• Department: Biological Sciences
• Course: BIOL 1412
• Professor: Paul Messing

Document Summary

Fe removed + stored (liver, muscle, spleen) from stores (or diet) bone marrow makes heme rbcs non iron portion bilirubin excreted in bile from liver jaundice: excess bilirubin in blood because: excess rbc breakdown; or liver dysfunction (neonates liver immature); or blockage of bile secretion converted to amino acid recycled. = process of stopping bleeding involves: vascular spasm vasoconstriction blood flow (min. to hrs. , platelets plug formation platelets stick to damaged blood vessels, release chemicals (factors) which: a. b. c. cause more platelets to stick (+ve feedback) promote clotting begin healing neighbouring healthy endothelial cells release a chemical preventing spread of plug plug formation requires a prostaglandin inhibited by aspirin, clot formation (fig. 1) extrinsic pathway uses pathway released by damaged tissues intrinsic pathway uses factors contained in blood usually both occur together require ca+, tissue, platelet and/or plasma factors prothrombin activator: prothrombin thrombin (plasma protein) thrombin, ca+2 c.