MIP 315A Lecture Notes - Portal Hypertension, Coeliac Disease, Liver Disease

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lemondog142

16 May 2014

School

CSU

Department

Microbio, Immun, Pathology

Course

MIP 315A

Professor

Gerald Callahan

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Document Summary

Villi lost surface area drops much less can be absorbed. If gluten is not in system, villi will be present. Atp metabolism is screwed up cell pumps dependent on atp fail water does not get absorbed. Know the symptoms of liver disease and their causes. Liver, gallbladder, and pancreas produce things which empty into small intestine. Protein production (most of those that are in the blood) Veins go from gut and stomach directly to liver. Liver problems blood does not flow easily. Varicose veins in the gut, have a tendency to bleed. Can be drained, but will come back unless something is done to fix liver function. Heme is broken into biliverdin broken into bilirubin. Bilirubin normally binds to albumin, travels to liver, combined into bile. With liver disease, albumin is not as available to pick up bilirubin. Characterized by fibrosis and the conversion of normal liver architecture into abnormal nodules. Among top 10 causes of death in developed world.

Related Questions

Itâs Friday morning and Sal Volpe is sitting in Dr. Lorraineâs exam room, dozing after another night of disrupted sleep. When the doctor knocks and walks in, she finds the 66-year-old man looking exhausted and uncomfortable. Sal gets to the reason for his visit immediately: Heâs been suffering from âstomach achesâ (dyspepsia) that wake him at night and nag him in between meals during the day. He describes his pain as gnawing, burning (maybe a 4 out of 10 on a pain scale) and points to the epigastric region of his abdomen. When he eats, he tells Dr. Lorraine, the pain goes away, but then he feels bloated and a little nauseated. The pain usually returns 2â4 hours later, depending on what he eats. Sal explains that he has had some pain relief from the over-the-counter drug PepcidÂ® (famotadine).

Dr. Lorraine proceeds with the history and physical exam. She discovers that Sal has a family history for gastrointestinal cancer and has unintentionally lost 10 pounds since his checkup a year ago. His epigastric area is modestly tender to palpation. She suspects a peptic ulcer (gastric or duodenal), but the weight loss and family history make it prudent to eliminate the diagnosis of stomach (gastric) cancer. âMr. Volpe, I think you may have a stomach or intestinal ulcer,â Dr. Lorraine says. âI suggest we perform an endoscopy to have a look. This involves passing a small tube with a small camera through your mouth and into your stomach. We can look at the wall of your stomach and small intestine, check for an ulcer, and remove a very small piece of tissue to test for infection. We call this a biopsy. Weâll also test the biopsy for cancer because of your family history. But, I really think weâre dealing with an ulcer here and not cancer.â

Later that month, the endoscopy is performed and it confirms Dr. Lorraineâs suspicions. Sal has a duodenal ulcer and infection with the bacterium Helicobacter pylori (H. pylori). This is not surprising since H. pylori is the cause of most peptic ulcer disease, particularly in the duodenum. Treatment involves complete eradication of the H. pylori with two different antibiotics, and a drug that decreases gastric acid secretion, a so-called proton pump inhibitor (PPI). Dr. Lorraine explains to Sal, âMr. Volpe, you do not have stomach cancer, but you do have a duodenal ulcer caused by the H. pylori bacteria I was telling you about. Too much acid and inflammation from this infection is causing your pain. The good news is we can probably cure your ulcer by killing the bacteria, but you will have to take three different medications twice a day for 14 days. Iâll see you again in 3 weeks; we can do a simple breath test to determine if the H. pylori has been successfully eliminated.â

Short Answer Questions:

The structures in the epigastric region share a common nerve supply. Can you name the specific cranial nerve that serves this region and the part of the nervous system to which it belongs?

In order to understand the disease in Mr. Volpeâs alimentary canal, one must know the layers that make up its walls. Design a chart that identifies the four basic layers of the alimentary canal, the tissues that make up each layer, and the general function of each layer.

Dr. Lorraine suspects a peptic ulcer. This is an inflammatory lesion in the stomach or duodenal mucosa, which may extend through all layers of the alimentary canal wall. Describe the basic histological (tissue) structure of the mucosa layer in the alimentary canal. Identify the unique features of the mucosa in the stomach and in the duodenum, and explain how this uniqueness determines the function of the stomach and the duodenum.

Mr. Volpe asks, âWhat do the bacteria have to do with the ulcer?â Dr. Lorraine tells him that the H. pylori increases stomach acid secretion and, at the same time, breaks down the lining of your stomach and duodenum. What is the source and normal function of acid in the stomach and what regulates its production

Why is Mr. Volpeâs dyspepsia relieved by food, and aggravated 2â4 hours after a meal?

coffeesheep473

1. Diseases are those abnormal conditionsin which the bodys defensive cells fail to make the self versus thenonself distinction correctly, and attack the body's owntissues.
A. Cancerous
B. Septic
C. Autoimmune
D. Nondiscrete

2. Which of the following determinesgenetic sex (male or female) in mammals?
A. the acrosome of the sperm
B. the temperature of the developing fetus
C. the SRY gene on the Y chromosome
D. the genetic makeup of the parents
E. the Y chromosome contained in the egg

3. Which of the following regardingantigens is true?
A. Antigens can only be recognized by their specificity.
B. An antigen is a molecule which promotes a general immuneresponse.
C. A large antigen is likely to have many different epitopes, eachof which can stimulate a distinct immune response.
D. The most effective antigen are small simple amino acidcomplexes.
E. Bacteria do not contain antigens.

4. All of the following are defensemechanism employed by vertebrates except

A. negative test, as in, not findingself-markers.

B. change in chromosomal composition

C. positive test to recognize presence ofnonself-markers

D. specific antibodies.

E. skin and mucous membranes asbarriers.

5. The immune system depends on thefunction of ______, which include several types of phagocytic cellsand two kinds of lymphocytes.

A. platelets

B. leukocytes

C. target cells

D. erythrocytes

6. In comparing the kidneys of marine andfreshwater fish, which of the following is not true?

A. Freshwater fish fluids have a greaterosmotic concentration.

B. Marine fish excrete many of the divalentcations through the anus.

C. The flow of the filtrate is faster inmarine fish.

D. The urine is less concentrated infreshwater fish.

E. Marine fish drink greater quantities ofwater.

7. The kidneys of which one of thefollowing are so highly efficient that it never has to drink waterand can obtain all of its water from its food?

A. desert lizard

B. camel

C. pocket moue Perognathus

D. kangaroo rat

E. gerbil

8. Select the incorrect statement regardingthe temperature of the immune system.

A. Interleukin-1 is a pyrogen, which cancause the neurons in the hypothalamus to raise the body'stemperature, producing a fever.

B. Fevers cause the liver and spleen tostore sodium and potassium which bacteria need for their growth andmetabolism.

C. Fevers above 105 Â° F can be fatal.

D. Fever contributes to the body's defensesby stimulating phagocytosis.

E. When macrophages encounter invadingcells, they release interleukin-1, which is carried to the brain bythe circulatory system.

9. Which of the following is not amechanism to prevent polyspermy?

A. change in membrane otential of egg

B. vitelline envelopes lift off surface ofegg

C. sperm nuclei degraded inside eggallowing one to fuse

D. cortical granule enzymes remove spermreceptors from egg

E. altering composition of exterior eggcoat

10. Which of the following cells have anincorrect function?

A. neutrophil---important antigenpresenting cell

B. eosinophil---important to theelimination of parasites

C. mast cell---releases histamine

D. macrophage---phagocytic cell

E. monocyte---precursor of macrophage

11. Which part of the antibody moleculedetermines its role in the immune response?

A. disulfide chains

B. the entire molecule

C. the stem of the Y

D. the heavy chains

E. two arms of the Y

12. Select the incorrectly matchedimmunoglobin (Ig)subclass and a fact about it.

A. IgG---found in the plasma and secretedin secondary response

B. IgM---first secreted during primaryresponse

C. IgE----promotes the release ofhistamine

D. IgA----found in saliva and motherÃ¢â¬â¢smilk

E. IgD----serve as receptors on thesurfaces of T cells

13. _______ are the source ofantibody-producing cells.

A. B cells

B. Plasma cells

C. Monocytes

D. Macrophages

E. T cells

14. Select the incorrect statementregarding the inflammatory response.

A. The alarm signals can be histamines orprostaglandins.

B. The inflammation response is a localizedspecific response to infection or injury.

C. Neutrophils spill chemical in the areaof injury or infection that kills bacteria, tissues, andthemselves.

D. Tissue can exhibit edema from thedilation of the blood vessels in the area of injury orinfection.

E. If a cell is injured or infected, itreleases chemical alarm signals that promote dilation of bloodvessels at the injury site.

15. Reproduction in reptiles compares toreproduction in birds in that

A. both newly hatched birds and reptilesrequire parental care.

B. the eggs of both birds and reptiles haveprotective shells.

C. birds are oviparous, reptiles areovoviviparous.

D. both exhibit external fertilization.

E. male or female reptiles reproduceasexually; birds do not.

16. ______diseases are those abnormalconditions in which the bodyÃ¢â¬â¢s defensive cells fail to make theself versus the nonself distinction correctly, and attack thebodyÃ¢â¬â¢s own tissues.

A. Cancerous

B. Septic

C. Autoimmune

D. Nondiscrete

17. Most marine invertebrates areosmoconformers. This means that

A. the osmolality of their body fluids isequal to that of the osmoregulators who inhabit the sameenvironments.

B. the osmolality of their body fluidsfluctuates between being hypertonic to hyportonic depending on theseason and the tides.

C. the osmolality of their body fluids isnot the same as their seawater environment

D. the osmolality of their body fluids isthe same as their seawater environment and that their bodiescontain the same solutes as their surroundings

E. the osmolality of their body fluids isthe same as their seawater environment

18. Which of the following determinesgenetic (male or female) in mammals?

A. the acrosome of the sperm

B. the temperature of the developingfetus

C. the SRY gene on the Y chromosome

D. the genetic makeup of the parents

E. the Y chromosome contained in theegg

If you can please explain why and how yougot the answer. 5 star rating for correct answers only, I have theanswer sheet, and just want to double check.

jadesnake579

Please help me check my answers and correct them if needed.Thank you!

1. Which statement regarding malnutrition is true?

	Malnutrition of one nutrient may directly and indirectly affectonly one system
	All nutrient deficiencies typically manifest in a matter of daysor weeks.
	Most cases of malnutrition in the elderly are directly relatedto a loss of appetite
	Nutritional homeostasis should primarily be achieved bydietary alterations.

2. Movement of the stomach/stomach lining upward into esophagusor diaphragm is termed what?

	Gastric reflux
	Gastric torsion
	Hiatal hernia

3. Which of the following is a function of the liver?

	produce and secrete insulin
	produce and secrete glucagon
	metabolize drugs
	excrete drugs from the body
	store red blood cells

4.
Which of the following regarding malnutrition is true?

	ingestion of supplements will prevent malnutrition
	malnutrition can be avoided if the recommendations of the foodpyramid are followed
	malnutrition in the United States is rare

5. What is protein-carbohydrate malnutrition? A person who:

	doesn't eat enough protein or carbohydrates
	eats to much protein and not enough carbohydrates
	eats to much carbohydrates and not enough protein
	eats to much protein and carbohydrates which interferes withabsorption and digestion of other nutrients

6. Which vitamin is stored in the tissues?

	A
	B
	C

7. The menstrual occurs within 3 or 4 days of which of thefollowing changes in the blood?

	increase in estrogen and decrease in progesterone
	increase in progesterone and decrease in estrogen
	increase in progesterone and estrogen
	decrease in progesterone and estrogen

8. Which statement regarding sperm production and aging istrue?

	Aging increases the amount of sperm produced
	Aging has a variable effect on the amount of spermproduced.
	Aging causes major changes in sperm cell morphology
	Aging causes major changes in sperm cell function

9. Which of the following is a function of the digestivesystem?

	Helping with speech
	Vitamin A production
	Storing blood in the pancreas
	Producing erythropoietin

10. Thinning of the enamel, decrease in nerve cells, recedinggums and loss of muscle of mastication coordination are consideredto be what type of changes in the mouth?

	Abnormal changes
	Age changes

11. A decline in sexual activity with age is primarilyassociated with what age related changes in the physiology of amale?

	Decline in frequency of use
	Deteriorating self-image
	Medication use
	Changes in blood flow

12. Which of the following conditions is not apathological change that effects the stomach?

	Peptic ulcer
	Atrophic Gastritis
	Acute Gastritis
	Stricture

13. Which of the following is an age related cause for fecalincontinence?

	Laxative use
	Ulcerative colitis
	Colorectal cancer
	Disability
	Stool softener

14. A decrease in lactase secretion is an age related changeassociated with the _____________.

	stomach
	small intestine
	large intestine
	pancreas

15. Which of the following statements regarding atrophicgastritis is true?

	causes overproduction of HCL
	causes overproduction of intrinsic factor
	increase absorption of B12
	increase risk for cancer

16. Functional incontinence may be due to a problem withwhat?

	cognitive function
	autonomic system
	urinary bladder
	urethra

17. Which of the following is not a function of nutrients?

	energy for activities
	raw materials for growth
	buffer to maintain pH
	fluid and electrolyte balance

18. Adenosine triphosphate is produced during all of thefollowing processes, except ______.

	Oxidative phosphorylation
	Kreb's cycle
	Electron transport
	Glycation

19. The digestive system helps create nutritional homeostasis,which of the following is one of the four reasons for nutritionalhomeostasis?

	nutrients are formed to supply the energy for vitalfunctions
	nutrients supply raw materials to synthesize body substances
	nutrients counteract against blood so that volume ismaintained
	nutrients tear down worn out substances for later use

20. Women with _____ percent body fat has an increase risk for ashorter life span and weight related diseases.

	18
	22
	27
	31

21. What amount of protein should be consumed daily by an olderadult?

	.25 gram per kilogram of weight
	.5 gram per kilogram of weight
	.75 gram per kilogram of weight
	1 gram per kilogram of weight

22. Stress incontinence is much more common in women than in menbecause women have which of the following?

	longer urethra
	premenopausal thinning
	weakened structures

23. Which of the following is an age related change affectingthe kidneys?

	increase in weight
	increase in width
	decrease in area
	decrease in volume

24. Postmenopausal decrease in estrogen leads to age relatedchanges of the _________.

	Urethra
	Urinary bladder
	Ureter
	Kidney

25. _______ percent of the working capacity of both kidneys isneeded to maintain homeostasis.

	10
	20
	30
	40

26. Which of the following is considered a treatment for urinaryincontinence?

	surgical removal of the sphincter
	medications to modify bladder function
	electric shock therapy

27. Which reproductive hormone provides a decrease risk ofatherosclerosis?

	testosterone
	relaxin
	estrogen
	follicle stimulating hormone

28. Which form of cancer in the female reproductive system rankssecond in occurrence?

	Ovarian
	Cervical
	Endometrial
	Vaginal

29. Which hormone produced in females seems to stimulate thelibido?

	Estrogen
	Progesterone
	Testosterone
	Luteinizing hormone

30. Which of the following regarding prostate cancer istrue?

	it is related to having benign prostatic hypertrophy
	it is more common in white males
	testing for prostatic specific antigen is sensitive andspecific
	it impairs the function of the liver

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MIP 315A Lecture Notes - Portal Hypertension, Coeliac Disease, Liver Disease

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