BMS 360 Lecture Notes - Coronary Artery Disease, Coronary Circulation, Cardiovascular Disease

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22 May 2014
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Understand that cardiovascular disease is the leading cause of death in the us. Understand what hypertension is and what the pathophysiological consequences of the disease are. Be able to describe what atherosclerosis is and understand the pathophysiological consequences of the disease. Be able to identify common risk factors for cardiovascular disease. Diseases of the cardiovascular system account for over 40% of all deaths in the us. Deaths due to total cardiovascular, lung, and blood disease: 43. 4% Inability of the heart to adequately deliver blood to the body. Blood backs up in the venous system and pulmonary circulation. Affects nearly 5 million americans (2% of the population) Secondary related to atherosclerosis, hypertension, etc. (very common) Involves thickening of the ventricular (usually left) and septal walls. Systolic function is normal but diastolic relaxation impaired. Hypertrophic cardiomyopathy is the leading cause of sudden cardiac death in young people. Loss of endothelial derived factors or impairment of their signaling pathways.

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