BMS 360 Lecture Notes - Parathyroid Gland, Bone Resorption, Anterior Pituitary
Document Summary
Strong negative feedback to hypothalamus and anterior pituitary. Increase protein catabolism and may cause muscle weakness. Exophthalmus, caused by hypertrophy of tissues in the eye socket, is a sign of hyperthyroidism. Understand the hypothalamic-pituitary regulation of growth hormone control. Understand the connection between bone formation and calcium balance. Know how plasma calcium levels are regulated by hormones. Understand the role of vitamin d in calcium plasma regulation. Gh and igfs required for protein and cell division. Chondrocytes synthesize new cartilage in center growth plate. Growth continues until closure of growth plate at puberty = epiphyseal closure. Figure 11. 29 cross section through piece of bone. Linear growth of long bones takes place at the epiphyseal plates. Oversecretion of gh in children leads to giantism. Oversecretin of gh in adults leads to acromegaly (malformation of bone) 99% body calcium calcified matrix of bone. Movement calcium in and out of bone determines blood plasma calcium levels.
