BMS 360 Lecture Notes - Nephron, Reabsorption, Arteriole
Document Summary
The concentration and only the concentration determines whether a substance is a toxin (paracelsus) Steady-state level of any chemical in the body is based on input (production, ingestion, administration) and output (metabolism, elimination) The liver and kidneys play major roles in input/output and regulate homeostasis of soluble molecules. The kidneys are located retroperitoneally at the level of the lower ribs. Afferent arterioles and glomeruli are all found in the cortex. There are about 1 million nephrons in each kidney. The glomerulus is the capillary network within the renal corpuscle. Structures associated with but not part of the nephron. Collecting ducts (multiple nephrons feed into a duct) Each nephron has two arterioles and two sets of capillaries associated with it. The diameter of the afferent arteriole is larger than the efferent arterioles, increasing blood pressure within the glomerulus capillaries to promote filtration. 20% of the plasma from the afferent arteriole is filtered into bowman"s capsule.
