BIOCH200 Lecture Notes - Protein Kinase, Pyruvic Acid
12 Jun 2014
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Under anaerobic conditions, the synthesis of ethanol or lactate consumes nadh and regenerate. Nad+: write an equation which describes the fate of pyruvate in anaerobic muscle, pyruvate + nadh + h+ = lactate, state why lactate is considered to be a dead end product for skeletal muscle, lactate cannot be converted to any other product except pyruvate, state how lactate is transported into the bloodstream from muscle cells and describe the metabolic advantage to the muscle of this process, lactate is transported via specific membrane transporter protein. Identify the source of the h+ ions that cause acidotic damage to muscle fibers during vigorous exercise: hydrolysis of atp by myosin during vigorous exercise can cause acidotic damage to muscle fiber, outline the route via which pyruvate moves from the cytoplasm into the mitochondrial matrix, glycolysis generates pyruvate in cytosol. Transport across the inner mitochondrial membrane requires the transporter protein pyruvate translocase.
