BCH210H1 Lecture Notes - Lecture 13: Adenylyl Cyclase, Cyclic Adenosine Monophosphate, Protein Kinase

• School: UTSG
• Department: Biochemistry
• Course: BCH210H1
• Professor: Stavroula Andreopoulos

Document Summary

Muscle response glycogen breakdown for energy production. Atp production in muscle goes up. Fat catabolism is also stimulated, atp increases. When blood glucose goes down glucagon (from the pancreas) is released. Liver is going to mobilize its glycogen or remove glucose from the non reducing ends. G- protein coupled receptors (gpcrs) are a class of membrane receptors that contain 7 tms. Gpcrs have an alpha subunit that is realised in the gtp bound form. Catabolism via g protein signalling. The reason why we are grouping these epinephrine and glucagon together is b/c they have similar signaling pathways. Cyclic amp (camp) acts as a secondary messenger to activate other enzymes. When either epinephrine or glucagon binds, you will get similar signaling pathway. So the alpha subunit is released = gtp bound. Gtp is bound in the active state and it can then go on and activate other proteins.