BIOL 3090 Study Guide - Midterm Guide: Wobble Base Pair, Start Codon, Kozak Consensus Sequence
Document Summary
Starting with lecture 10 on feb. 12 (page 127 in the new 6th edition: fig. 4-17 is a good review for protein translation: mrna is translated into protein by the joint action of trna and the ribosome, made of numerous proteins and 2 major rrna molecules. Base pairing occurs between trna anticodons and mrna codons. Synthetic transcripts now have 2 different nucleotides with 3 distinct reading frames trnas are good to know!! (figs. 4-19: charged trna has proofreading function; can recognize cognate trnas (anticodons) and other parts of the molecule, depends on both positive interactions and the absence of negative interactions. If it finds a wrong attachment, catalyzes the removal of the aa: the wobble base position (fig. Codon bound to anticodon: parallel or anti-parallel: anti-parallel. Inosine can form nonstandard base pairs with a, c, and u. It can recognize codons with these bases in the third position.
