PSL300H1 Lecture Notes - Lecture 2: Codocyte, Thyroid, Pituitary Gland

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25 Jun 2014
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6:23 am: there are 3 types of homones: o o o. Amine hormones(derived from single amino acids: peptide/protein. Linked amino acids, synthesized like many other secreted proteins. Made in advance, stored in vesicles, released by exocytosis o o: water soluble (dissolved in plasma) and lipophobic o o o. Signal seq + hormone (1+ copies) + cleaved peptide fragments. Post-translational processing produces biologically active peptide: synthesis, packaging and release. Shows the packaging of synthesis of hormones, an inactive hormone state. This newly premade prohormone is directed by a signal sequence in which it is o o cleaved into the endoplasmic reticulum. Prohormone, moved into transport secretory vesicles from golgi apparatus as it moves off the golgi complex, it is packaged with the peptide fragment or enzymes to cleave the prohormone to activate it fragment. Enzymes are essential to yield an active hormone and the peptide.

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