ANP 1105 Study Guide - Myofibril, Haemophilia B, Vasoconstriction

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Learning objective for blood part 2: hemostasis is the orderly, stepwise process for stopping of bleeding. It is regulated by a complex system of activators and inhibitors that maintain blood fluidity and prevent blood from leaving vascular compartments. Platelets release chemicals that make nearby platelets sticky; platelets plug forms: coagulation: fibrin forms a mesh that traps red blood cells and platelets; forming the clot, summary of hemostasis, coagulation: a. Intrinsic pathway: associated with endothelium rapture clotting of blood outside body: extrinsic pathway: clotting associated with body & blood vessel damage release of tissue factor bypass many steps of intrinsic pathway faster pathway to factor. X and pa: phase 2 of coagulation involves prothrombin (ii) to convert to thrombin (iia). Soluble (fibrolysis): hemostasis relies on procoagulation factors, whereas healthy vessels rely on anticoagulation factors. Normally flowing blood washes away procoagulants and as thrombin forms it limits clot size. Antithrombin ii and protein c inactivate many intrinsic pathway procoagulants.

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