MIP 342 Lecture Notes - Retrovirus, Antigen, Nucleoside
Document Summary
Flu-like disease (50 80% of cases) - 2 6 weeks. Symptomatic phase infections that show in immunocompromised patients. Aids if untreated, death within 1 year. Re-emergence of tuberculosis in the era of aids epidemics. The world health organization (who) declared tb a global emergency in 1993. 2 to 3 million people around the world die from tb every year. One third of the world"s population 2 billion people have been infected with tb, and therefore have the potential to develop active tb. The impact of tb is greatest on the poor; 99% of the deaths and 95% of all cases occur in the developing world. Decreases cd4, mhc class i and ii expression gp120 ligand for cd4 (used to bind to t cell, enveloped and taken in) Protease therapy target, cleaves polypeptide into functional protein units. Group of cells fuse gp120 of viral envelope interacts with cd4 and other coreceptors (other cells do not need to be infected first)