MIP 342 Lecture Notes - Red Pulp, Mycobacterium Leprae, Bone Marrow
Document Summary
Lag phase between exposure and response 7 10 days. B cells make antibodies/bcr, t cells use the tcr (conserved structures for antigen recognition) B cells have b cell receptor antibody attached to cell membrane. Specific antibody + bacterial toxins forms antigen:antibody complex, neutralization macrophage recognizes antigen:antibody complex, ingestion. Specific antibody + bacteria in extracellular space opsonization ingestion by macrophage. Specific antibody + bacteria in plasma complement activation lysis and ingestion. The epitopes recognized by t-cell receptors are often buried the antigen must first be broken down into peptide fragments the epitope peptide binds to a self molecule, an mhc molecule. The t-cell receptor binds to a complex of mhc molecule and epitope peptide. Antigen presentation of viral or bacterial peptides on major histocompatibility complex molecules (mhc) All cells have mhc i, in case of viral or intracellular infection. Only immune cells have mhc ii, to communicate to cd4+ (helper) t cells what they found.