Ammonium ion is a reasonable leaving group (l. g. ) Less-substituted alkene = preferred product after step 2 after step 1. Ochem page 1 more preferred conformation b/c less steric hindrance not gauche. Looks like tert-butyl but need this conformation to do e2 so n group and h must be anti. So long as it"s staggered, h is anti to leaving group. -> have a higher concentration of this --> higher rate. -> the h"s here are always ready to do e2 predict major product remember, look at c adjacent to leaving group. Identify h"s (from the c"s found above) that = anti (newman projection can helpbut harddraw chair conformations) Oxidation of amines: air will slowly oxidize amines (protect the lone pair by protonation --> sell as hcl salts) Primary amine r-nh2 -->[o] --> hydroxyl amine nitro nitroso for tertiary amines amine oxide. If r group has -hydrogens, cope elimination will occur upon heating. Think of it as oxygen as internal base.
