CHEM 2332H Lecture Notes - Opata Language, Fadd, Astronomy Picture Of The Day
15 Jul 2014
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Drawback: lialh4 is a very strong reducing agent and not as selective in reduction (reduces things that you might not want reduced) Advantage: very easy to control acylation; the first part of rxn is really reliable. If add pyridine in, it"s positive, so it"s a good leaving group and can be displaced by orignal reagent. Original one is positive, but can be deprotonated propose starting materials for acylation and reduction. Could break the ring as well but above answer is better. To get to starting materials of reductive amination, can replace the cl w/ h. Reductive amination is more versatile (relying on eqbmmight not always favorable), acylation/amination reduction is more reliable. Primary amine synthesis: if tried to do sn2 by ammonia, product could also do sn2. Nh3 + mei --> h2n-ch3 (not good rxn b/c product keeps reacting) Use nitrogen nucleophile that can only do 1 substitution, then convert to amine. Gabriel synthesis pretty acidic primary halides/tosylates do sn2.
