BIOL442 Lecture Notes - Lecture 8: Ribonuclease H, Retrovirus, Subtypes Of Hiv
16 Jul 2014
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Set 8 - retroviruses (+) strand rna viruses, but genome does not function as mrna as it does with other (+) strand rna viruses. Distinguishing feature is replication strategy; rna --> dna --> host chromosome --> rna. Features in common with both dna and rna polymerases. Other activities; helicase-like activity, rnase h activity (degrades rna in rna/dna hybrids) Long incubation period that characterizes the disease they cause. Include tumorigenic viruses, but not all appear to cause tumors, and other non-retroviridae can cause tumors e. g. , mouse mammary tumor virus, avian leukemia virus. Cause extreme vacuolization in infected cultured cells; bubbly appearance in cytoplasm; foamy viruses e. g. , simian foamy virus. 1% of primate hunters (baboons, chimps, monkeys) are infected (zoonosis) None of the foamy viruses have yet been confirmed to cause disease in humans or animals, but some are suspect. All retroviridaehave 2 identical copies of genome carried in capsid, associated with each other near 5" ends.
