BIO 3153 Study Guide - Final Guide: Tubulin, Microtubule, Cytoskeleton

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17 Jul 2014
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Cytoskeleton regulation: modify processes and cytoskeletal dynamics (ex. Dynamic instability, treadmilling) dynamic and under control of the cell (af, mt, if) Plant cytosol: microtubules then nucleate branching daughter microtubules gammaturc accelerates mt formation. Nucleation of mt by gamma-tubulin protein complex centrosome (mtoc) of animal cells, spindle pole bodies in yeast (- end) Gamma tubulin: conserved protein, forms ring structure with accessory proteins (gamma tubulin complex) that helps to initiate growth and formation by inducing nucleation at minus end. Divides and heads to poles of the cell to form mitotic spindles (makes network) 2 centrioles and 9 triplets of microtubules embedded/anchored. Organizes pcm (pericentriolermatrix material): material that fills centrosome. Lumen and pcm contains gamma tubulin (microtubules grow from it in centrosome) rescue and catastrophe and emanate in astral configuration) Nucleated/anchored from minus ends, plus ends point outward (undergo. Unbranched initation: cell periphery (cortex), where density is highest. Location related to af function (determine shape and movement)