BIO 3153 Study Guide - Final Guide: Spindle Apparatus, Motor Protein, Microtubule
17 Jul 2014
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Microtubules: astral o o o radiate in all directions from centrosomes forming, looking for attachment. Involved in anaphase b: kinetochore, attach to kinetochore at centromere, attach chromosomes to spindle o. Involved in: overlap o shape of spindle, allow net formation o. Involved in anaphase interdigitate at equator of spindle and are responsible for symmetrical biopolar contact with other microtubules produced by other centrosome. Chromosomes (chromatids: centrosome: begin nucleation and production of mt, centrioles, pcm: microtubules nucleated by pcm. Motor proteins contribute to spindle assembly: create foci at minus ends that form 2 spindle poles, slide antiparallel microtubules past each other in the overlap zone of the spindle. Minus end: plus end directed kinesin related proteins (krp) (ex. Mitosis: nucleation of centrosome not in mitosis but it occurs right before. G2: centrosome duplication (starts in g1, ends in g2) Prophase: mitotic splindle formation, centrosomematrix/centriole pair complex separates into 2 and nucleates aster, 2 asters move apart along outside of nucleus.
