BIO 3153 Study Guide - Final Guide: Myc, Cell Division, Apoptosis
17 Jul 2014
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Total cell mass: total cell mass = size of organ/organism. : controlling divisions and deaths (total cell mass dependent on): growth factors: increase synthesis, decrease degradation, mitogen: promotes progression through cell cycle and cell division, survival factors: decrease apoptosis. Pdgf: growth factor and mitogen, stimulate cell growth and cell cycle progression: covalently linked dimer with 2 receptor binding sites, directly cross links adjacent receptors to initiate intracellular signaling process. Pi 3-kinase, adds a phosphate to p2 activation of tor. Activates s6k (protein kinase) then s6 (ribosomal protein) activates targets in the cell that stimulate and increase protein synthesis. 1: tor: protein kinase whose mechanisms promote synthesis and inhibits degradation by activating, s6: ribosomal protein from which you"ll get transcription and translation, therefore protein synthesis and cell growth. *growth factors stimulate increased production of myc (activates transcription of genes that promote cell proliferation) Nerve growth factor: growth factors stimulate cell growth without affecting cell division.
