PHGY 350 Lecture Notes - Interferon, Basophil, Lipoxygenase

• School: Queen's University
• Department: Physiology
• Course: PHGY 350
• Professor: Allan R Baer

Document Summary

Readings (gould) (5th ed. ) p. 67 - 75 (4th ed. ) p. 15 26 (top left) Inflammation a protective response to eliminate the cause of injury (eg. microbe) and necrotic cells. Signs redness (erythema: vasodilation increases blood flow (hyperemia) swelling, edema (water leaking out of blood vessels) Anaphylaxis toxic response to innocuous agents chronic inflammation - cause may be persistent: eg. rheumatoid arthritis, ulcerative colitis. Ulceration - more susceptible to infection: ulcer: friction can erode surface of skin, dies, ex: decubitus ulcer scarring or swelling may compromise function. Vasodilation fluid & protein exudation: serous - watery - common in burns, purulent - contains dead cells = pus fibrinous - high fibrin content, leaves scar tissue. Neutrophil infiltration follows pre-existing macrophages in tissue chemotaxis - attracts neutrophils (follow gradient to target: bacterial peptides, complement, prostaglandins, etc. Neutrophils marginate (line vascular wall: attach via selectins: proteins.