Physiology 3120 Study Guide - Adipokine, Neighborhood Watch, Angiotensin

• School: Western University
• Department: Physiology
• Course: Physiology 3120
• Professor: Tom Stavraky

Document Summary

Lipid soluble (require binding proteins in serum: amino acid derivatives. Liver secretes angiotensinogen (angiotensin precursor), igf-i & thrombopoietin ( platelets) Fat produces many adipokines (ex. leptin: cells produce locally-acting growth factors and cytokines. Factors affecting hormone action: hormone production/release, regulation of gene expression by other hormones and cytokines, availability of necessary substrates, enzymes and energy, more hormone at a given target cell will lead to activation of more receptors (until saturation) Innervation (in certain cells innervation of cells to make hormones: constant exposure to high levels of hormone may eventually lead to down-regulation of receptor in target cell(s) receptor desensitization. Signal amplification: each hormone/receptor complex produces multiple second messenger molecules (ex. camp, each second messenger molecule activates different signaling cascades (protein. Pkc, ca++) phosphorylation: end result is generation of multiple copies of an mrna, functional phosphorylated protein etc, variable release rate into blood, fine tunes physiological responses, prevents receptor down regulation, attenuates negative feedback due to constant exposure, ex.