HMB300H1 Study Guide - Midterm Guide: Transient Global Amnesia, Acetylcholinesterase Inhibitor, Retrosplenial Cortex
Document Summary
Sws dominated by serotonergic system of raphe nuclei. Sws need low cortisol, low acerylcholine (hippo feedback to cortex needs to be activated for consolidation) Dissociates from membrane allowing more vesicle release of. Acetylcholine levels too low in alzheimer and demensia. Prozac (ssris) block serotonin reuptake increase level at synapse. Tcas (tricyclic antidepressants) block reuptake of ne and/or serotonin. Compensatory upregulation / increased sensitivity of post synaptic receptors more nts are bound at receptors decrease in reuptake and transporter binding. Amphetamine binds to monoamine transporters increases noradrenergic activity / neuronal signal. Increases: excocytosis of receptors, psd/spine head size/post synaptic density, and trafficking of receptors + activates retrograde messenger (increases vesicle number presynaptically / high prob of release through pkc. Nt transporter gene short allele (polymorphism mutation in vntr region of promotor) More of a hallucinogen) x-irradiation increased hpa axis activity sleep deprivation. Deletion of a repeat less protein being made (not shorter protein).
