BIOC14H3 Lecture : lec 17
Document Summary
Dna methylation differences occurs in the promoter and in the exons of the gene into the. Maternal care can have a huge affect on the number of different processes and behaviours. Prof talked about his research : tried to look at the regulation of gene expression through. D epigenetic mechanism as a funciton of early maternal care in rat. They used a microaarrray approach where they immunoprecipitated either the component sof chromatin or dna methylation. What they did was precipitated the dna with an antibody that recognized dna methylation. So you have a fraction of sample with an enriched population of dna methlyation, and then you compare that sample with the same individual with their standard dna with both methylated and un-methylated fractions. You can see where the areas are enriched and the pop has both methylated and un- methylated dna. Individuals with low maternal or high maternal care mothers you can see where they show enriched methylation.
