IMM250H1 Lecture : Notes taken during lecture

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19 Dec 2011
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T cells derive from thymus, right above heart, in btw lungs. T cells like b cells antigen specific. Diversity of t cells generated by somatic recombination. Unlike b cells huoral produce antibodies. Tcr v similar to fab fragment of ig. Constant and variable regions of light and heavy chain. Antigen binding site at most distal portion of molecule. Dimer of two different chains alpha and beta chains. Cysteine residues allow disulfide bond dimer receptor. Recognize peptide antigen which are fragments of protein. Top figure three diff epitopes ig recognize epitopes exposed at surfce of proteins, recognize two kinds of epitopes. Linear epitopes formed by continuos amino acids. Conformational epitopes distant portions of amino acids segments on protein brought together when protein folds. Tcr recognition recognize peptide drived from protein some peptide epitopes epxosed at surface, like blue . Tcr access to peptide antigen not accesible to ig, because buried in protein when protein folds.

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