NROB60H3 Chapter Notes - Chapter 5: Cholecystokinin, Dynorphin, Vasoactive Intestinal Peptide

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Synaptic transmission: process of information transfer at a synapse. Synapse: area where one neuron transfers information to another at this specialized area. Existence of electrical synapses proven in 1959 when rushpan and potter studied ns of crayfish electrical synapses are common in mammalian brain. Alternative hypothesis about nature of synaptic transmission was that chemical neurotransmitters transfer information form 1 neuron to another at the synapse. Box 5. 1: otto loewi and vagusstoff (137) Information tends to flow in 1 direction, form a neuron to target cell/ 1st cell is presynaptic and target cell is postsynaptic. Gap junctions : electrical synapses occur at specialized sites, membranes of 2 cells are separated by 2 nm and is spanned by clusters of special proteins called connexions. 6 connexins make channel called connexon, 2 connexons combine to form gap junction channel (allows ions to pass directly from cytoplasm of 1 cell to cytoplasm of another)

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