MIMM 465 Chapter 11: How Bacteria Became Resistant to Antibiotics
20 Dec 2011
School
Department
Course
Professor
Document Summary
Chapter 11: how bacteria became resistant to antibiotics. reduced uptake across cytoplasmic membrane y prevents entry of antibiotics into cytosol, where it has to act y y however, sometimes the antibiotics use a transporters, as is the case for. resistance to macrolides y atp-dependent efflux system that pumps macrolides out of cell in. Staphylococcus species y however, it only works on some macrolides y the protein shares homology with many atp dependent transport proteins. resistance to quinolones y no protein has actually been identified, but there is some evidence of an efflux system. It should occur together with some other mechanisms, such as less uptake of fluroquinolones. In staphylococci, they pump streptogramins out of the cell using efflux pumps y enzymatic inactivation of antibiotics: done by either hydrolyzing or adding chemical groups to important part of antibiotic, there are quite a few mechanisms: They cleave the c-n bond in the ring.
