Biochemistry 2280A Lecture : Topic 11

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Eat food catabolic pathways (break down larger molecules into smaller building blocks in order to extract useful forms of energy and reducing power) lose energy as heat. Building blocks are used in the anabolic pathway to make larger molecules. Product of one is a substrate for the next one. Flux = rate of movement through the pathway, want the delta g to be negative (all the way from a don t want any to be positive). About 0 around equilibrium but a couple are negative and these drive the reaction forward. If one is positive get stuck at that point. Products are strongly favoured reaction is still very negative so changing the reactants a little bit won t affect the reaction. The forward reaction is dominating too much therefore irreversible reactions. Gibbs free energy is so negative that it won t happen/ For 3 reactions they are irreversible because the delta g is too negative. (big slope)

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