BCH210H1 Lecture : Tutorial notes
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BCH210H1 Full Course Notes
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Linear chain of amino acids to final structure of protein called protein folding, the process. Levinthal s paradox basically proof that folding must be directed in some method. If fold randomly on their own, proteins probably wouldn t actually fold, take too long. Idea that primary sequence enough to determine overall structure \ Some part of primary structure forms a secondary structure quickly done. Backbone can only take one of few conformations. Hydrophoic effect dominant in folding: help form structure, collapse of small units - small secondary units driven by hydrophobic effect, beginning nnucleation of tertiary structure, helices stable, stabilized by hydrophobic effect, final folding of other residues. Certain regions are formed first because more stable, rest are formed upon that. Happen with alpha helices, beta strands even combination of both can be first things formed. Proteins activity can look at activity, when active, must be folded properly: not folded properly, won t function.