Anatomy and Cell Biology 4429A Lecture : Protein Folding
Document Summary
Chaperones allow proteins to fold, 1/3 of the proteins that are folded do not fold properly and have to be disposed of. Hsp70 delivers proteins to the lysosomes or proteosomes if you are a misfolded proteins. A small fraction of proteins can fold on their own and some fold with the help of a molecular chaperone. Some proteins don"t do any of one of these three things pictured in the diagram and find themselves aggregated together in insoluble clumps. Cells are not very good at not very good at unfolding proteins. The pathway this protein is involved with will be rerouted to a different pathway or will stop. The protein could also do something new which might be toxic to the cell, or undergo a gain of function. Accumulation - if there is a mutation and this protein isn"t targeted to be destroyed, these proteins might accumulate.