Anatomy and Cell Biology 4429A Lecture : Cancer
22 Dec 2011
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Compared to this, cancer is a fairly rare disease. Loss of heterozygosity - mutated copy of an rb. At the time of chromosomal replication, you"ve duplicated the normal and the harmless version. At the end of g2, you cross over the ends of chromosomes. Every time you go through a round of mitosis, you could get a daughter cell that contains two bad copies of rb. In cells that are undergoing mitosis, i could use the heterozygosity. You need these six things to become a metastatic cancer (ten years ago). If you can do all of these things but can"t evade apoptosis, as soon as you have dna damage, the cell will die. These are not cancerous yet, however they have lost their ability to maintain their architecture. If you get enough changes, these adenomas will now become carcinomas. Hyperproliferative - tissues that have lost the ability to stop mitosing.
