BIOC14H3 Lecture : BIOC14 : Lec 17 : Movie - The Ghost in Your Genes

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The rules of inheritance broke down y angelman s syndrome: what mattered was the origin of the chromosome 15 that had the deletion. If deletion is on chromo 15 of dad = pw. If deletion is on chromo15 of mom = a. There must have been a tag or imprint placed on that chromo during egg/sperm formation. Functioning differently; although dna sequence is the same, the different sets of genes were being silenced depending on whether it came from mom or dad. found: increased occurrence of this epigenetic syndrome in the ivf population. although beckwith-wiedemann syndrome is very rare, the risk increased 3-4x with ivf. seems that simple act of removing embryo from its natural enviro could trigger the disease: everyone thought any altered switches couldn t be inherited. study: took mice with altered gene switches and bred them.

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