Biology 3332A Study Guide - Final Guide: Calpain
22 Jan 2012
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These findings suggest that antigen stimulation of cd4+ helper t cells results in production of cytokines that kill or down regulate cd8+ t suppressor cells. Disguise hypothesis: coat selves with host components, either make them themselves or absorb them from the host. Not realistic for the parasite to make the components itself because it would have to have a huge genome with all the genes for antigens of any host it may infect. Mechanically transformed juvenile worms to shed their tails so they are now juveniles (schistosomula) instead of cercariae. Mice had been pre-infected and then their infection cleared so they have an existing immune response against the parasite. Result: both groups were killed having the disguise did not protect the serum-grown worms, hence arguing against the disguise hypothesis as a mechanism by which parasites avoid the immune system. Alternative hypothesis: juvenile parasites are susceptible to adcc and cmi.
