IMM250H1 Final: Tutorial notes + exam questions
Document Summary
Special k situation - low responder mouse, which means hole in t cell repertoire of certain mouse strain, that cannot recognize antigen x within mhc expressed in that strain. Assume p1 is balbc non-responder to special pan x black 6 is high responder, meaing it can recognize antigen x within mhc class. Mouse is f1 high-responder animal response to antigen presented by. Separate different t cell populations on basis of restriction. Use different pans that have antigen presenting cells plus antigen. No population able to kill targets that are h2d plus x while have population found in adherent cells when use h2b plus x plate and non-adherent population when use h2d plus x cells. Hole in repertoire refers to antigen x only **** Low responder t cell repertoire has no tcr able to see special case antigen x in context of certain mhc allele because hole in repertoire. Know the rules in lecture 3 *********************8.
