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BIOB11H3 Lecture : Continuation of Chapter 12 and 13 (Summer2011)

Canada

Molecular Aspects of Cellular and Genetic Processes

Biological Sciences

Rosada Silva

University of Toronto Scarborough

Life on Earth: Unifying Principles

Human Physiology II: Lecture and Laboratory

Animal Physiology

Ecology

Evolutionary Biology

Biochemistry I: Proteins and Enzymes

Biochemistry II: Bioenergetics and Metabolism

Genes, Environment and Behaviour

Techniques in Analytical Chemistry

Introduction to Environmental Science

Introduction to Business

Introductory Psychology: Part I

Introductory Psychology: Part II

<p><p>Micro RNAs (miRNA) recognize their target mRNAs based on sequence complementarity. MiRNA cause the inhibition of protein translation by degradation of the mRNA. How might dysregulation of miRNAs be involved in cancer via tumor suppressor genes?</p></p>

<p><p>Which of the following is true of the process of eukaryotic mRNA degradation? Select all that apply.</p> <table style="width:410px;"> <tbody> <tr> <td style="vertical-align:top;width:12px;"></td> <td>The 5' cap is removed.</td> </tr> </tbody> </table> <table style="width:410px;"> <tbody> <tr> <td style="vertical-align:top;width:12px;"></td> <td>The exosome degrades the mRNA to individual nucleotides.</td> </tr> </tbody> </table> <table style="width:410px;"> <tbody> <tr> <td style="vertical-align:top;width:12px;"></td> <td>Degradation can be at least partially carried out in processing bodies.</td> </tr> </tbody> </table> <table style="width:410px;"> <tbody> <tr> <td style="vertical-align:top;width:12px;"></td> <td>The poly(A) tail is lengthened.</td> </tr> </tbody> </table></p>

One way of regulating eukaryotic gene expression is to control the life time of the messenger RNA. mRNA degradation occurs by different mechanisms. Briefly describe the miRNA (microRNA) pathway that leads to mRNA degradation.

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