Microbiology and Immunology 3300B Lecture : Immunology Notes

39 views4 pages

purplejackal117

20 Feb 2012

School

Western University

Department

Microbiology and Immunology

Course

Microbiology and Immunology 3300B

Professor

Rodney Dekoter

For unlimited access to Class Notes, a Class+ subscription is required.

Document Summary

Stimulating a b cell: bcr signalling complex like t cell, antigen specific signal. Apc function interactions with t cells (cd40 signal is important for activating b cells). Stimulating a b cell: the first signal required for b cell activation is delivered through the antigen receptor (the antigen is displayed as a peptide on mhc class ii). A second signal is required for b cell activation. In thymus-dependent (t cell dependent) antigens the signal is delivered by a helper t cell that recognizes the peptide. There is an interaction between cd40l on the t cell and cd40 on the b cell. In thymus- independent antigens, a second signal can be delivered along with the antigen itself through tlrs that recognize lps (bacterial polysaccharides can induce antibody production in the absence of helper t cells). Ti-1 antigens: are antigens coupled to a tlr ligand such as lps or bacterial dna.

Related Questions

Which of the following is/are the most specific internal defense against disease?

T cells

inflammation

NK cells

phagocytes

A class I MHC protein presents an antigen. What type of cell is likely presenting and to what type of cell would it be presented?

Any nucleated cell would be presented to a CD8 cell.

An antigen-presenting cell would be presented to a CD4 cell.

An antigen-presenting cell would be presented to a T helper cell.

Any nucleated cell would be presented to a CD4 cell.

What types of antigen do T cells NOT recognize?

processed fragments of protein antigens displayed on surfaces of body cells

indicate whether you think the statements are true or false, and explain your reasoning. In each of your answers, provide 1-2 specific examples that support your position. (Each of your four answers is worth five points):

A) Memory cells require fewer distinct signals to be activated than naiÌve cells require.

B) Both B cells and T cells undergo âclonal selectionâ after they are activated by antigen.

C) A B cell is only able to present antigen to a T cell that includes the epitope to which the

B cellâs receptor bound.

D) T cells can recognize peptide antigens in the context of MHC I and MHC II regardless of

whether they are Thelper or Tcytotoxic cells.

E) B cells and T cells can both still make productive antigen receptors via V(D)J

recombination even if no P-nucleotides are introduced during the process.

F) Allelic exclusion takes place when a naiÌve T or B cell encounters its specific non-self antigen for the first time and determines whether or not to become activated.

G) B cells have more chances to make a productively rearranged antigen receptor than T cells do.

H) A majority of immature T cells developing in the thymus will survive both positive and negative selection.

I) The reason why T cells are the only type of white blood cell that requires maturation in a specialized organ outside the bone marrow is because they are the only ones that must have antigen processed and presented to them before they can be activated.

violetbear615

Like T cells, B cells require multiple signals for activation. Antigen binding to the B cell antigen ______ provides one signal, while antigen-specific effector ______ provide the other signals. The requirement for multiple signals to activate either a T cell or a B cell helps to prevent ______ and dangerous activation of monocytes , including ______ ______ . Most of the proteins involved in cellâcell recognition and antigen recognition in the immune system, including ______, TCRs, and ______ proteins, as well as various co-receptors, belong to the ancient Ig superfamily. This superfamily is thought to have evolved from a primordial gene encoding a single Ig- like ______ . The mechanisms for diversifying antibodies and T cell receptors by recombining gene segments may have arisen when a ______ inserted into an exon of a gene encoding an Ig family member.

receptors (BCRs) helper T cells killer T cells
inappropriate appropriate monocytes
lymphocytes self-reactive non-self-reactive
antibodies IPR MHC
domain transposon retrovirus

tanmacaw520

Microbiology and Immunology 3300B Lecture : Immunology Notes

Document Summary

Get access

Related Documents

Microbiology and Immunology 3300B Lecture Notes - Lecture 3: Genetic Recombination, Glycolipid, Granulocyte

Microbiology and Immunology 3300B Lecture Notes - Lecture 8: Cd154, Mhc Class Ii, White Pulp

Microbiology and Immunology 3300B Lecture Notes - Lecture 6: Monocyte, Lysozyme, Granzyme

Related Questions