BPS 1101 Lecture Notes - Agostino Bassi, Louis Pasteur, Gerhard Domagk

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peargoldfish669

2 Mar 2012

School

University of Ottawa

Department

Biopharmaceutical sciences

Course

BPS 1101

Professor

William Ogilvie

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Death is wear n" tear it used to be infections!) People thought it was due to god, therefore would search for reasons why god was mad (burn heretics, etc. ) If you were lucky, the treatments were harmless. People who had knowledge of the disease fled from the area. You were left with plague doctors : they would cover themselves from head to toe and wear beak mask with spices with strong scents (thought it was due to unhealthy airs). Antibiotics are the second best health invention in human history! Life expectancy has dramatically increased due to such things as antibiotics and vaccinations (now main cause of. Bubonic plague: mortality rate maybe 25%, and in some areas the mortality was 50% Post natal infections were common therefore maternal mortality rate was 30% Surgery survival rate was less than 30% If you had any kind of surgery, you would likely die from infection.

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For each term listed below, be able to provide a definition and brief description of its relevance to global health

Health (WHO definition)

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You are treating a skin infection by a bacteria in a human. Younotice that there are two genotypes of bacteria in the infection,C1 and C2. You first check to see what the relative fitness of thetwo types before treating the patient. You give an antibiotic andrecheck the fitnesses with the results shown i the table.

Genotype	C1	C2
No antibiotics	1	1.02
Antibiotic treatment	1	.6

For each of these two situations, calculate what the frequencyof allele 1 would be for the next TWO generations, starting fromp=.2.

Which of these alleles is resistant to the antibiotic?

If you could leave the infection untreated by antibiotics, whatwould the frequency of the resistant type be after a long time?

**Please show your work!!

Thanks!

yellowhornet175

Paraphrase this please. In conclusion, we can prevent antibiotic resistance by avoiding infections. It helps to reduce the amount of the antibiotic used and reduces the likelihood that antibiotic resistance would develop and ways to avoid those infections. Furthermore, some of the preventive measure of antibiotic resistance includes hand washing, preparing food safely, vaccinating people, and infections control in healthcare settings and farms. Most importantly, we also need better test to diagnose what the illness causes by and which antibiotics would help and use antibiotic only when needed as prescribed.

BPS 1101 Lecture Notes - Agostino Bassi, Louis Pasteur, Gerhard Domagk

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