BIO120H1 Lecture : Notes taken during lecture
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BIO120H1 Full Course Notes
Verified Note
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Document Summary
Cell signalling pathways in quite a bit of detail for today. each pathways unique protein involved, signals involved. different signals different responses to each. no signal alpha bound to gdp off. receptor activated induces conformational change in alpha subunit, which causes gdp to dissociate, and gtp binds in its place. gtp binding causes further conformational change: activated alpha subunit dissociates from beta and gamma. both can now regulate activity of target proteins. prolonged stimulation receptor becomes inactive, even if ligand is bound. arrestin bound to receptor on cytosolic side. receptor either endocytosed for degradation or it can be recycled for further use to its pathway. pka is a kinase will phosphorylate glycogen synthase to inhibit glycogen synthesis. promotes breakdown of glycogen : so cell can release glucose, also involve phosphorylation phosphorylate glycogen phosphorylation kinase. gpk phosphorylates glycogen phosphorylase: name of protein tells you the target****
