BIO120H1 Lecture : Notes taken during lecture

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redtermite204

16 Feb 2011

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yeast do mate alpha and beta mating types. possible to activate one cassette independent of another. Jak/stat enzyme associated receptor through protein protein interactions. Jak1, jak2, jak3 : each with different substrate specificity. receptor phosphorylation for docking, for phosphorylation of stat, stats dimerize. binds to dna turning on or off gene: stat is a transcription factor. erythropoiesis generation of red blood cells. dimer that binds is either smad 2/3 or smad4 dimer. don"t need to know example of target gene. Turning off a pathway: different ways, know www. notesolution. com. target gene in nucleus, smad6 or 7, expressed after a delay (activate rna, fold ) block smad 2/3 from binding , interacting with receptor. **to study: draw pathway from me mory; will forget parts, study those; then start with fresh blank piece of paper, and draw the pathway from me mory again; repeat. ethylene is plant hormone, binds to ethylene receptor.

Related Questions

Choose only one correct answer

QUESTION 1

Transautophosphorylation occurs in which two of the followingsignaling pathways?

a.GPCR and RTK pathways

b.RTK and Integrin/FAK pathways

c.S/TKR and PKA pathways

d.GPCR and Ras pathways

e.MAPK and cAMP pathways

QUESTION 2

Which of the following receptors are activated by GTP?

a.G protein coupled receptors only

b.tyrosine kinase receptors only

c.both G protein coupled receptors and tyrosine kinasereceptors

d.neither G protein coupled receptors nor tyrosine kinasereceptors

QUESTION 3

Why can both GPCR and RTK pathways activate calmodulin?

a.Because both activate PLC

b.Because both activate PI3K

c.Because both trigger an action potential

d.Because both activate Ras

e.Because both activate PKA

QUESTION 4

Ion channel receptors __________ enzymes. They __________ bindsignaling ligands.

a.are, do

b.are not, do

c.are, do not

d.are not, do not

QUESTION 5

PIP2 is cleaved by ___________ to produce _____________.

a.phosphodiesterase, DAG and IP3

b. phospholipase C, DAG and IP3

c. phosphodiesterase, DAG and calcium

d. phospholipase C, DAG and calcium

QUESTION 6

Why are integrins considered to be signaling proteins?

a.Because they bind ECM

b.Because they bind heterotrimeric G proteins

c.Because they bind FAK

d.Because they bind MAPK

e.Because they bind Sos

QUESTION 7

Why isnât tubulin considered a G protein?

a.Because it doesnât propagate a signal in a signalingpathway

b.Because it doesnât bind to GPCR

c.Because it doesnât bind to a GEF or a GAP

d.Because it doesnât undergo transautophosphorylation

e.Because it doesnât bind GTP

orangebutterfly756

1.What makes adenylate cyclase a signalingprotein?

2. The mitogen-activated protein kinases (MAPKs) are among the most commonly used proteins kinases in cells. They are often employed by the cell in protein kinase cascades, where MAP3K phosphorylates and activates MAP2K, which in turn phosphorylates MAPK. What are the possible advantages for the cell to employ a protein kinase cascade?

bluedeer608

1. When a growth factor binds to a receptor tyrosine kinase, the receptor becomes phosphorylated on tyrosine residues.

a. How does this occur?

b. Why is this phosphorylation important in initiating an intracellular signaling cascade?

c. Why does phosphorylation change the activity of proteins? (What happens to the protein physically when it is phosphorylated?)

aquamarineporpoise419

BIO120H1 Lecture : Notes taken during lecture

BIO120H1 Full Course Notes

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