HMB200H1 Lecture :
Document Summary
Evidence that during middle pregnancy gabaergic controlling neurons protection against emotional disorders that happen when loss of control. Epileptic seizures sometimes bizarre feelings & experiences just before seizure (auras) overactivation of glutamate neurons: frontal cortex funny; amygdala emotional; hippo experiences, loss of inhibition. Movement away from basic dopamine fns & basic neurotransmitter theories of depression: something about these transmitters can interact w higher brain changes in limbic system. Movement away from brainstem transmitters to limbic system disruptions perspectives. Not many difs from other mammals in our brain except for prefrontal cortex. Schizo left temporal lobe delusions disordered speech. 1950s believed mental disorders untreatable until antipsychotic drugs (chlorpromazine/chlorazine) found: neuroleptics discovered via trial & error. Work on dop neurons particularly by blocking dop2 recs: 1970s seeman, john hopkins grp, follow recs understand how disorders work. 1980s: antidepressants, lithium, ssris & benzos: 1 per decade, no great breakthrus since 1990s: prozac & ssris.