BIO130H1 Lecture 6: Lecture 6
31
BIO130H1 Full Course Notes
Verified Note
31 documents
Document Summary
1: dna repair o o o o. Leading strand is synthesized continuously from single rna primer o. Lagging strand is synthesized discontinuously from multiple primers: okazaki fragments consist of the rna primer and the dna strand, dna synthesis proceeds in 5" to 3" direction o. What happens at the ends of chromosomes? o o. The primer space is programmed by primosome to space them in specific distances: over successive rounds of replication, a gradual shortening of 5" ends of the newly synthesized strands, particularly in lagging strands you lose sequence information. As you migrate through the double stranded dna, particularly in lagging strand which is initiated by primers, the primers run out of template. What happens at the ends? repeated sequences in the 3" ends of strands which allows the replication. The ends are called telomeres and they provide access points for primers to be initiated. The t-loops are usually tucked back into the chromosome.
