BIO120H1 Lecture 8: Lecture 8

• School: UTSG
• Department: Biology
• Course: BIO120H1
• Professor: Darrel Desveaux

Document Summary

Intracellular vesicular transport part 2: sorting and packaging in the golgi. Lecture 8: cargo from er to cis golgi network, cargo packaged in copii-coated vesicles. exit signal: bound by cargo receptors. other cargo have no exit signal, but are packaged because of [high] in er: copii-coated vesicles bud from er exit site. fuse with each other to form vesicular tubular clusters: vesicular tubular clusters move to golgi apparatus by microtubules, retrieval (retrograde) transport, retrieval transport: copi-coated vesicles. vesicles from vesicular tubular clusters and golgi to er: vesicles contain: proteins involved in vesicle budding from er: retrieval of er-resident proteins from the golgi, many er resident proteins have er retrieval signals, soluble er proteins. packaged into copi-coated transport vesicles: er membrane proteins. example of signal = kkxx at c-terminus. packaged into vesicles: retrieval of er-resident proteins from the golgi, kdel receptor cycles between er and golgi.