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BIOL 200 Lecture Notes - Macromolecule, Peptide, Conformational Change

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School
McGill University
Department
Biology (Sci)
Course
BIOL 200
Professor
Richard Roy

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Document Summary

Logic would dictate that if there are more mrna molecules within a cell, this should correlate to more proteins being synthesized. A first method of regulation can occur during translation by altering the stability of the mrna molecules. An example is the mrna for mammalian transferrin receptor, which is responsible for importing iron into the cell. The stability of mammalian mrna molecules coding for the mammalian transferrin receptor (tfr) is mediated by an iron response element binding protein (ire-bp) Ire-bp, has two conformations which depend on iron concentration within the body: it is inactive in high iron concentration, it is active in low iron concentration. Tfr mrna contains au rich sequence with secondary structure on its 3" utr called iron response elements (ires: these ires are capable of binding ire-bps. In high iron concentrations, the ire-bps are inactive and cannot bind to the mrna: the mrna is therefore degraded by exonucleases and the transferrin receptor proteins cannot be expressed.

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