PSL301H1 Final: PSL301 Final Exam Test Study Sheet.docx
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PSL301H1 Full Course Notes
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Document Summary
Hematocrits formed elements; blood cells and the like. Phagocytes leukocytes that can engulf things via phagocytosis. Cytokines released molecules, eg proteins, that act to signal/cause infammation. In embryo these cells come from: yolk sac, liver, spleen, bone marrow: after birth only from bone marrow. Hematopoiesis: 75% hematopoietic stem cell become erythrocytes, 25% become leukocytes, erythroblast reticulocyte erythrocyte, megakaryocyte breaks down into platelets. P a g e | 2: colony stimulating factors from endothelial cells and white blood cells regulate process via cytokinesis. Granulocyte colony stimulating factor induces creation of neutrophil rather than monocyte. Red blood cells: no nucleus, anaerobic metabolism, life span 120 days. Erythropoiesis: regulated by erythropoietin synthesized in liver and kidneys in response to low oxygen, nucleus pinches off nomoblast to form retiulocyte which matures to erythrocyte. Bilirubin secreted by liver in bile and by kidneys as urine: bilirubin causes jaundice. Due to high turnover of red blood cells.
