EESA10H3 Lecture Notes - Lecture 4: Biomagnification, Bioaccumulation, Biomonitoring
Document Summary
Direct: chemicals bind to the hormone receptor. Some appearance of the gene can be altered which may lead in the inaccurate protein production. Indirect: can cause lower or higher level of the hormone production: these endocrine disrupters do not cause really severe effects in human adults. Example 2: des prescribed to prevent spontaneous abortion. Although the mothers and their kids were okay, the grandchildren had problems (listed on the slide). Endocrine disrupters: feminization of males in roosters. Besides physiological impacts, the behaviors were altered as well. Prenatally, pcb"s cause the problems listed on the slide. This research is coming from animal studies and not human. What are the body burdens: every year 100"s of new chemicals are released into the environment, those chemicals need to have approval, however sometimes the approval is not based on research. Sometimes they are used even before we have a good risk assessment: there are no individuals on this planet without chemicals in their body.