BIO130H1 Chapter : Pg.1010-1022.docx
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BIO130H1 Full Course Notes
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Motor proteins: bind to cytoskeleton filament and move along actin/microtubule. They carry cargo and differ in the direction that they are moving. Motor proteins can carry membrane enclosed organelles such as mitochondrion, vesicles and golgi stacks. The motor proteins interact with filaments using their heads and hydrolyzes. Actin-based motor proteins are members of the myosin superfamily. Myosin ii: two heavy chains and two light chains; long amino acid sequence. Each myosin head binds and hydrolyzes atp. Many different types of myosin were discovered. All myosin move to the plus end of the actin filament except myosin vi. There are two types of microtubules motor protein: kinesin and dyneins. Kinesin: motor protein that moves along microtubules. Identified first in the axon of a squid. Has two heavy chains and two light chains. Most walk towards the plus end of the microtubule. Dynesin: minus end directed proteins of microtubules. 2 or 3 chains that vary in combination of light and dark chains.